Institute of functional genomics

Fields of research

Systems biology of malignant and non-malignant diseases; Development of analytical tools for the high-throughput systematic characterization of genomes, transcriptomes, proteomes and metabolomes of cells, tissues and biofluids; Structural, functional and comparative genomics

Research projects

  • Tumor metabolism and immune escape
  • Graft-versus-host disease in stem cell transplantation – identification of predictive/prognostic biomarkers and deep sequencing of 16S rDNA isolated from stool specimens
  • Novel strategies for the treatment of acute childhood lymphoblastic leukemia
  • Role of mutated Fanconi.associated protein (FAP) in hereditary renal tubulopathy
  • Proteomics and metabolomics of non-alcoholic steatohepatitis
  • NMR and GC(xGC)-TOFMS based metabolite fingerprinting
  • Metabolite Fingerprinting in dairy cows; Bioinformatics of high-content data
  • Autosomal dominant polycystic kidney disease (ADPKD)
  • Urine and serum metabolite and protein fingerprinting in chronic renal disease
  • Hyphenated mass spectrometry of amino acid enantiomers

Co-operations

  • Bruker BioSpin GmbH, Rheinstetten, Germany
  • LECO Instrumente GmbH, Mönchengladbach,Germany
  • Georgia Chenevix-Trench, The Queensland Institute of Medical Research, Brisbane, Australia
  • Christian Singer, Medical University, Vienna, Austria
  • Reinhard Kofler, Medical University Innsbruck, Austria
  • Kai-Uwe Eckardt, University Clinic Erlangen, Germany
  • Ruedi Fries and Heinrich Meyer, Technical University Munich, Freising-Weihenstephan, Germany

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